Research Progress on the Controlled Construction of Nanocellulose@MOF Composite Materials

Abstract

Metal–organic frameworks (MOFs) are crystalline hybrids in which metal nodes and organic linkers stitch into ordered nets through coordination bonds. They couple ultra-high surface area and tunable porosity with straightforward, often room-temperature syntheses, propelling them to the forefront of drug-delivery research. Yet residual metal leaching and ligand degradation still raise cytotoxic red flags, curtailing wider biomedical use. In recent years, studies have shown that the cyclodextrin metal-organic framework (γ-cyclodextrin metal-organic framework, CD-MOF) composed of γ-cyclodextrin and potassium ions has safe and non-toxic components and good biocompatibility, which can solve the practical application shortcomings of MOFs in drug delivery, effectively improve the stability of guest drug molecules, and enhance efficacy, making it a highly potential drug carrier. This article will review the synthesis and safety of CD-MOF, as well as its advantages and limitations as a drug carrier.